TABLE 3.
Binding affinity of selected toxin-specific MAbs, as measured by Bio-Layer interferometry
| MAb | Kd (M) | Kon (M−1 s−1) | Kon error | Koff (s−1) | Koff error |
|---|---|---|---|---|---|
| A2 | <LOQa | 3.56 × 105 | 2.16 × 103 | <LOQ | 3.16 × 10−6 |
| B1 | 4.77 × 10−11 | 5.85 × 105 | 4.34 × 103 | 2.79 × 10−5 | 3.73 × 10−6 |
| B2 | 7.97 × 10−11 | 4.20 × 105 | 3.18 × 103 | 3.35 × 10−5 | 3.92 × 10−6 |
| B3 | 4.87 × 10−10 | 1.93 × 105 | 1.45 × 103 | 9.40 × 10−5 | 3.73 × 10−6 |
| B4 | 1.21 × 10−10 | 5.31 × 105 | 4.46 × 103 | 6.44 × 10−5 | 4.26 × 10−6 |
| B5 | 2.02 × 10−10 | 4.77 × 105 | 2.15 × 103 | 9.62 × 10−5 | 2.35 × 10−6 |
| B6 | <LOQ | 7.30 × 105 | 4.61 × 103 | <LOQ | 3.13 × 10−6 |
a
LOQ, limit of quantitation.