TABLE 6.
Neutralizing activity of combinations of anti-toxin B MAbs against increasing concentrations of C. difficile toxin B in the Vero cell assaya
| MAb combination | Results for MC50 times: |
|||||||
|---|---|---|---|---|---|---|---|---|
| 12 |
36 |
108 |
324 |
|||||
| NT50 (pM) | Maximum % completeness | NT50 (pM) | Maximum % completeness | NT50 (pM) | Maximum % completeness | NT50 (pM) | Maximum % completeness | |
| B2+B1 | <67 | 90 | 107 | 91 | >133,333 | 86 | >133,333 | 14 |
| B2+B4 | 1,667 | 69 | >133,333 | 7 | >133,333 | 11 | >133,333 | 0 |
| B2+B6 | 107 | 84 | 700 | 93 | 4,433 | 90 | >133,333 | 37 |
a
The data are the average of ≥3 experiments.