Table 2.

Family History of MI Associated with Incident CHD with or without Adjustment for Covariates in the WHI-OS Diabetic Cohort

	Unadjusted			Adjusted for age and duration of diabetes Med			Fully adjusteda
CHD (n = 377)	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
FHx (yes)	1.43	1.16, 1.75	0.0003	1.44	1.18, 1.77	0.0004	1.50	1.20, 1.87	0.0003
≥2 relativesb	1.69	1.31, 2.18	<0.0001	1.67	1.30, 2.16	<0.0001	1.79	1.35, 2.35	<0.0001
1 relativeb	1.27	1.003, 1.61	0.047	1.31	1.03, 1.65	0.03	1.34	1.04, 1.73	0.024
Prematurec	1.38	1.11, 1.71	0.004	1.43	1.15, 1.78	0.001	1.42	1.13, 1.79	0.003
Late onsetc	1.22	0.99, 1.51	0.06	1.18	0.96, 1.46	0.12	1.28	1.02, 1.60	0.03
MI/coronary death (n = 113)
FHx (yes)	1.03	0.71, 1.49	0.9	1.04	0.72, 1.51	0.83	1.13	0.75, 1.70	0.55
≥2 relativesb	1.05	0.63, 1.74	0.86	1.00	0.60, 1.66	0.98	1.08	0.63, 1.88	0.77
1 relativeb	1.02	0.67, 1.55	0.93	1.07	0.70, 1.64	0.75	1.16	0.73, 1.85	0.52
Coronary proceduresd (n = 264)
FHx (yes)	1.66	1.30, 2.12	<0.0001	1.68	1.31, 2.15	<0.0001	1.71	1.31, 2.24	<0.0001
≥2 relativesb	2.08	1.54, 2.80	<0.0001	2.08	1.54, 2.81	<0.0001	2.21	1.15, 3.06	<0.0001
1 relativeb	1.41	1.06, 1.89	0.02	1.44	1.09, 1.92	0.01	1.45	1.07, 1.97	0.017

^aAdjustment for additional covariates: systolic and diastolic blood pressure, years of smoking (20+, 10–20), race, education (≤ high school), income (<$50 000), hypertension medication, lipid lowering medication, hysterectomy, use of HRT, waist/hip ratio, physical activity, and alcohol consumption.

^bNumber of family relatives with MI compared to no family relative with MI

^cAt least one relative with MI first onset at age <55 years for men and/or <65 years for women defined as premature, otherwise, as late onset. The comparison group was family relatives free of MI.

^dIncludes: percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass angioplasty (CABG), and stent placement. CHD, coronary heart disease; FHx, family history; MI, myocardial infarction; HR, hazard ratio; CI, confidence interval.