Table 5.

a. Best sensitivity and specificity for serum biomarkers to predict good vs. poor outcome at 6 months.
	Concentration (ng/ml) Good/poor outcome	Sensitivity	Specificity	Positive predictive value	Negative predictive value
S100b
24 h (best sensitivity)	0.001	0.96	0.29	67.6	83.3
24 h (best specificity)	0.128	0.40	1.00	100.0	53.1
48 h (best sensitivity)	0.008	0.96	0.59	77.4	90.9
48 h (best specificity)	0.283	0.20	1.00	100.0	45.9
NSE
24 h (best sensitivity)	2.15	0.96	0.12	62.5	66.7
24 h (best specificity)	53.10	0.20	1.00	100.0	45.9
48 h (best sensitivity)	0.48	0.96	0.18	63.2	75.0
48 h (best specificity)	76.71	0.24	1.00	100.0	47.2
MBP
24 h (best sensitivity)	0.08	1.00	0.18	65.0	100.0
24 h (best specificity)	5.83	0.04	1.00	100.0	40.5
48 h (best sensitivity)	0.05	1.00	0.06	61.0	100.0
48 h (best specificity)	5.43	0.12	1.00	100.0	43.6

b. Best sensitivity and specificity for serum biomarkers to predict mortality at 6 months.
	Concentration (ng/ml) Good/poor outcome	Sensitivity	Specificity	Positive predictive value	Negative predictive value
S100b
24 h (best sensitivity)	0.001	0.96	0.29	45.9	100.0
24 h (best specificity)	0.128	0.40	1.00	100.0	81.3
48 h (best sensitivity)	0.008	0.96	0.59	81.8	77.4
48 h (best specificity)	0.283	0.20	1.00	100.0	70.3
NSE
24 h (best sensitivity)	2.15	0.96	0.12	48.5	90.0
24 h (best specificity)	53.10	0.20	1.00	100.0	73.3
48 h (best sensitivity)	0.48	0.96	0.18	53.6	92.9
48 h (best specificity)	76.71	0.24	1.00	80.0	67.6
MBP
24 h (best sensitivity)	0.08	1.00	0.18	42.5	100.0
24 h (best specificity)	5.83	0.04	1.00	39.5	60.5
48 h (best sensitivity)	0.05	1.00	0.06	70.0	71.9
48 h (best specificity)	5.43	0.12	1.00	100.0	63.4

NSE, neuron specific enolase; MBP, myelin basic protein