Figure 2.

Deletion of periostin led to local changes of Ocys and a sharp increase in SOST in the PKO jawbone, but no Ocy morphology changes in the long bone. A) Representative radiographs reveal bone loss in PKO alveolar bone (right). B) Acid-etched scanning electron microscopy images display a sharp change of Ocys in jawbones from spindle to round in PKO mice. C) Acid-etched scanning electron microscopy images display no apparent change of Ocys in PKO long bone. D and E) The immunohistochemistry stain images display a dramatic increase in SOST in the PKO mandibular bone (D, right), and the quantitative data showed that the ratio of the SOST-positive Ocys:total Ocys is significantly different between the WT and PKO jawbones (a total of 1064 Ocys were counted in 3 pairs of groups) (E).