Figure 3.

Restoration of bone loss in the Sost-Periostin DKO and Scl-Ab-treated PKO mice. A) Representative radiographs reveal a restoration of bone loss in the PKO jawbone by removing the Sost gene (right; DKO). B and C) The μCT data display the restoration of bone qualitatively (right images in B) and quantitatively (lower panel in C). D) Backscattered scanning electron microscopy images confirm the rescue of bone loss in DKO mice (right). E) The acid-etched scanning electron microscopy images reveal a direct correlation between changes in Ocy morphologies and the surrounding matrices in PKO (defects; middle) and DKO (rescue; right) compared to the age-matched control (left). F) Representative radiographs reveal the restoration of bone loss in the PKO by Scl-Ab treatment. G and H) The μCT data display a restoration of BV in the PKO mice qualitatively (lower right in G) and quantitatively (lower panel in H). The yellow arrows point to white mineral rings, and the white arrow indicates a poorly formed matrix with low minerals. **P < 0.01; *P < 0.05 (n = 5).