Figure 5.

Restoration of bone loss, defective CEJ area, and defective Ocy morphology in the 5-month-old PKO after Scl-Ab treatment for 8 weeks. A) Representative radiographic images display severe bone loss in the nontreated PKO jawbone (red arrow) and recovery of bone loss in the treated group (green arrow). B) The μCT images confirm the radiographic observation (left), and quantitative μCT data show that this change was statistically significant. C) Representative μCT images display an increase of CEJ area (pink) in the PKO mice, which was restored in the antibody treatment group (green arrow), and the quantitative analyses show that the CEJ changes in the PKO mice are significant compared to either the age-matched control or treatment group. Note that 5 animals per group were selected for a μCT scan. The images were rotated so that the crown pulp and root pulp are connected and perpendicular to the horizontal plane for estimation of the CEJ area (red color) through >100 “cutting” slides across the mandible. **P < 0.01 (n = 5). D) Representative backscattered scanning electron microscopy image reveals an expanded canalicular and lacunar system in the nontreated PKO group, which was fully reversed in the treated group. White arrow indicate lack of mineral along the canalicular systems.