Table 2.

Age, breast PD (%), and selected texture features in BRCA1/2 gene-mutation carriers, unilateral cancer patients, and the low-risk controls (SD, standard derivation; CI, confidence interval). Bold implies statistical significance achieved.

Datasets	Number of cases	Mean age (SD)	Range	$p$-value	Mean PD (SD)	$p$-value (95% CI of $\mathrm{\Delta }P\mathrm{D}$)	Texture: mean coarseness × 104 (SD)	$p$-value (95% CI)	Texture: mean log2(contrast) (SD)	$p$-value (95% CI)
BRCA1/2	34	46.9 (9.3)	34 to 72	0.2065	23.1 (17.7)	0.7134 [$-0.0871$, 0.0587]	5.72 (2.64)	$\mathbf{3.9}\mathbf{E}-\mathbf{5}$ [0.86, 2.36]	3.86 (1.35)	$\mathbf{8.0}\mathbf{E}-\mathbf{4}$ [$-\mathbf{1.30}$, $-\mathbf{0.35}$]
Low-risk	136	48.9 (7.9)	32 to 71		24.4 (19.8)		4.11 (1.79)		4.68 (1.24)
BRCA1	24	48.5 (9.7)	34 to 72	0.9188	22.5 (19.2)	0.7395 [$-0.1037$, 0.0738]	5.37 (2.47)	0.003967 [0.40, 2.10]	4.02 (1.26)	0.02163 [$-\mathbf{1.17}$, $-\mathbf{0.09}$]
Low-risk	96	44.7 (9.3)	32 to 74		24.0 (19.7)		4.11 (1.70)		4.65 (1.17)
BRCA2	10	43.2 (7.5)	35 to 57	0.5504	24.3 (14.4)	0.4653 [$-0.1986$, 0.0922]	6.57 (2.97)	$\mathbf{6.08}\mathbf{E}-\mathbf{4}$ [1.22,4.19]	3.47 (1.53)	$\mathbf{4.3}\mathbf{E}-\mathbf{2}$ [$-\mathbf{2.26}$, $-\mathbf{0.44}$]
Low-risk	40	44.6 (6.4)	32 to 57		29.6 (21.6)		3.87 (1.82)		4.82 (1.21)
Unilateral cancer	67	58.8 (12.9)	35 to 89	0.9071	20.8 (17.3)	0.3835 [$-0.0266$, 0.0689]	4.77 (1.64)	$\mathbf{1.21}\mathbf{E}-\mathbf{4}$ [0.46, 1.40]	4.13 (1.01)	$\mathbf{9.5}\mathbf{E}-\mathbf{6}$ [$-\mathbf{1.09}$, $-\mathbf{0.43}$]
Low-risk	268	59.0 (12.6)	32 to 88		18.7 (17.9)		3.84 (1.78)		4.89 (1.28)