Figure 8.

Disease comorbidities network are constructed by applying the multiplex network model. Each disease is denoted by the ICD-9-CM code. (A) is a comorbidity association network based on the gene disease association data. (B) is a comorbidity association network based on the pathway disease association data. (C) is a comorbidity association network based on the clinical information. (D) is a comorbidity association network based on the integrated multiplex network output of the input of (A–C) as layers of the model.