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. 2015 Mar 31;2(2):021013. doi: 10.1117/1.NPh.2.2.021013

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© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Fig. 6 — Chronic whisker deprivation did not significantly affect layer 5 pyramidal neuron-driven excitatory responses and feedback inhibition. (a) Diagram showing the photostimulation of layer 5 neurons in column C. The blue dotted box indicates the photostimulation area while the solid box indicates the area of interest where responses from (c) and (e) are taken from. (b) Similar input–output curves of layer $2 / 3$ responses following photostimulation of layer 5 pyramidal neurons for control (black) and deprived (red) slices. Maximum LED power was used for photostimulation experiments in the rest of the study. Integrated layer $2 / 3$ responses were integrated from 7.4 to 25 ms after the onset of the light flash. (c) Averaged optical traces of layer 5 responses following photostimulation of layer 5 pyramidal neurons for control (black) and deprived (red) slices. 3 ms photostimulation indicated by the black bar below the trace. Deprived responses were slightly larger than controls but not significantly so. (d) Histogram of excitatory responses at layers $2 / 3$ , 4, and 5 of column C following photostimulation of layer 5 in (a). Excitatory responses were not significantly different across all layers. Integrated responses at various layers were integrated from 7.4 to 25 ms after the onset of the light flash. (e) Averaged optical responses elicited at layer 5 following photostimulation of L5 pyramidal neurons in column C for control (black) and deprived (red) slices. 3 ms photostimulation indicated by the black bar below the trace. Subtracted compound IPSPs were similar between control and deprived slices. (f) Histogram of compound IPSP responses at layers $2 / 3$ , 4, and 5 following photostimulation of L5 pyramidal neurons in column C as in (a). Compound IPSP responses were not significantly different across all layers, suggesting that experience-dependent plasticity involves interneurons not driven by layer 5 pyramidal cells. Integrated compound IPSP responses at various layers were integrated from 11.8 to 51.4 ms after the onset of the light flash.