Figure 1. CSF ferritin associates with ApoE levels and varies according to APOE genotype.

(a,b) Modelling ferritin in CSF (refer to, M3 of Supplementary Table 1). Minimal multiple regression contained CSF ApoE and APOE ɛ4. (a) Scatterplot of CSF ApoE and ferritin levels in APOE ɛ4 carriers and non-ɛ4 carriers. The genotype did not affect the relationship between ApoE and ferritin; however, genotype is associated with CSF ferritin levels, and thus ɛ4 carriers and non-ɛ4 carriers are plotted separately. The R² for the linear component of the full model was 0.341 (displayed on graph). (b) CSF Ferritin levels in APOE ɛ4 carriers and non-carriers (ANCOVA: P-value=1.10 × 10⁻⁸). (c) Multiple regression of CSF ApoE. ApoE levels in APOE ɛ4 carriers and non-carriers (ANCOVA: P=2.50 × 10⁻⁹). Data are means+s.e. ‘n' is represented in graph columns.