Figure 2. CSF ferritin levels independently predict cognitive status.

(a–c) Multiple regression of baseline ADAS-Cog13 score expressed as tertiles of CSF (a) ferritin (L<5.5; H>7.3 ng ml⁻¹), (b) ApoE (L< 5.8; H>7.8 μg ml⁻¹) and (c) tau/Aβ_1–42 (L<0.35; H>0.76). (d) Multiple regression of baseline RAVLT score expressed as CSF ferritin tertiles. Data are adjusted for baseline diagnosis, gender, years of education and the AD CSF biomarkers in the minimal models. Data are means+s.e. ‘n' is shown in graph columns. CN, cognitively normal; MCI, mild cognitive impairment.