Table 1. Baseline characteristics of subjects from the ADNI cohort used in this study, stratified by diagnosis.
| Units | CN | MCI | AD | P-value | |
|---|---|---|---|---|---|
| n | — | 91 | 144 | 67 | NA |
| Age | Years (s.d.) | 75.74 (5.43) | 74.85 (7.2) | 74.57 (7.61) | 0.502 |
| Female | n (%) | 46 (50.55) | 47 (32.64) | 29 (43.28) | 0.021 |
| Education | Years (s.d.) | 15.67 (2.94) | 15.91 (2.95) | 15.01 (2.96) | 0.123 |
| APOE-ɛ4 +ve | n (%) | 22 (24.18) | 75 (52.08) | 46 (68.66) | 6.50 × 10−8 |
| ADAS-Cog13 | Units (s.d.) | 9.51 (4.16) | 19.19 (5.94) | 29.22 (8.21) | 2.75 × 10−56 |
| CSF Ferritin | ng ml−1 (s.d.) | 6.4 (2.07) | 6.95 (2.72) | 6.94 (2.99) | 0.591 |
| CSF ApoE | μg ml−1 (s.d.) | 7.3 (2.21) | 7.1 (2.22) | 6.35 (2.27) | 0.012 |
| CSF tau | pg ml−1 (s.d.) | 69.78 (28.01) | 104.3 (52.41) | 122.63 (57.47) | 4.57 × 10−7 |
| CSF ptau | pg ml−1 (s.d.) | 24.77 (13.34) | 36.39 (16.09) | 41.39 (20.76) | 1.13 × 10−6 |
| CSF Aβ1-42 | pg ml−1 (s.d.) | 205.31 (56.38) | 161.06 (52.06) | 142.16 (36.84) | 2.29 × 10−6 |
| CSF tau/Aβ1–42 | Units (s.d.) | 0.39 (0.26) | 0.75 (0.5) | 0.94 (0.52) | 7.80 × 10−9 |
| Hippocampus | mm3 (s.d.) | 7,219.6 (848.6) | 6,230.9 (1,047.8) | 5.766.6 (1,283.2) | 6.71 × 10−20 |
| Lateral ventricle | mm3 (s.d.) | 34,052.62 (16,528.1) | 44,842.52 (23,574.05) | 49,902.53 (26,896.68) | 3.35 × 10−5 |
AD, Alzheimer's disease; CN, cognitively normal; CSF, cerebrospinal fluid; MCI, mild cognitive impairment. Unadjusted unit values are presented in the table. P values presented for ANCOVA models of CSF analytes and MRI brain structure were adjusted for age, gender, years of education, BMI, APOE genotype, CSF haemoglobin and CSF Factor H. Intracranial volume was also included in ANCOVA models of brain structure.