Table 3.
Brain regions showing significant correlations with clinical Y-BOCS subscores for obsessions and compulsions
| Region | Clusterlevel | T-value | MNI-space | P-value | ||
|---|---|---|---|---|---|---|
| x | y | z | SVC | |||
| Negative correlation between ADC-maps and Y-BOCS scores for compulsions in OCD. | ||||||
| Right sub-gyral | 638 | 9.33 | 38 | −1 | −21 | 0.001 |
| Left sub-gyral | 4325 | 8.60 | −30 | 16 | 18 | 0.001 |
| Left anterior cingulate | 547 | 7.41 | −10 | 31 | 17 | 0.003 |
| Left cingulate gyrus | 257 | 6.20 | −8 | −36 | 31 | 0.010 |
| Left lingual gyrus | 347 | 6.00 | −14 | −68 | −2 | 0.013 |
| Left posterior cingulate | 266 | 5.97 | −3 | −42 | 21 | 0.013 |
| Left extra-nuclear | 1637 | 5.96 | −32 | −6 | 25 | 0.013 |
| Left lentiform nucleus | 287 | 5.74 | −11 | −3 | −2 | 0.017 |
| Left insula (BA 13) | 347 | 5.41 | −31 | −25 | 14 | 0.025 |
| Positive correlation between MTI-maps and Y-BOCS scores for obsessions in OCD. | ||||||
| Left inferior parietal lobule WM | 138 | 7.48 | −54 | −42 | 44 | 0.005 |
| Left middle temporal gyrus (BA 39) GM | 1051 | 9.25 | −49 | −61 | 22 | 0.001 |
| Left Cuneus (BA 18) GM | 195 | 5.63 | −2 | −79 | 20 | 0.030 |
| Left Cerebellum/Culmen | 103 | 5.35 | −4 | −47 | −9 | 0.039 |
Cluster size = number of voxels; x,y,z = Coordinates (in mm) of significant local maxima are given for information in MNI space (Montreal Neurological Institute, http://www.bic.mni.mcgill.ca). BA: Brodmann area. For regions where an effect was hypothesized a small volume correction (SVC) was performed. P values are given after family wise error (FWE) correction for the particular volume.