Skip to main content
. Author manuscript; available in PMC: 2016 May 27.
Published in final edited form as: J Agric Food Chem. 2015 May 19;63(20):4999–5007. doi: 10.1021/acs.jafc.5b01307

Table 2.

Biological screening of the essential oils from A. kotuchovii

Biological Activity AKEOf/l AKEOstm
IC50 (µg/ml)
LPS-induced NF-κB/AP-1 activity in THP-1Blue cells N.A. N.A.
LPS-induced TNF production in MonoMac-6 cells N.A. N.A.
Neutrophil elastase enzymatic activity N.A. N.A.
fMLF-induced Ca2+ flux in human neutrophilsa N.A. 12.5 ± 2.7
fMLF-induced chemotaxis in human neutrophilsb N.A. 10.1 ± 3.1
PMA-induced ROS production in human neutrophilsc N.A. 49.2 ± 5.4
a

Activity was evaluated as inhibition of Ca2+ flux induced by 5 nM fMLF in neutrophils.

b

Inhibition of chemotactic activity in neutrophils was evaluated in the presence of 0.5 nM fMLF.

c

Inhibition of ROS production in neutrophils was evaluated in the presence of 200 nM PMA and 40 µM L-012 . N.A.: no activity was observed, even at the highest concentration tested (50 µM).