Table 1.
Post-TBI pathophysiology | Acute symptom / clinical correlate |
---|---|
Ionic flux | Migraine headache, photophobia, phonophobia |
Energy crisis | Vulnerability to second injury |
Axonal injury | Impaired cognition, slowed processing, slowed reaction time |
Impaired neurotransmission | Impaired cognition, slowed processing, slowed reaction time |
Protease activation, altered cytoskeletal proteins, cell death | Chronic atrophy, development of persistent impairments |