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Peri-adolescent maturation of dendritic spine density on the apical (A) and basilar (B) dendritic trees of layer III pyramidal neurons in the medial PFC takes place primarily during early adolescence. Group means ± standard errors of the mean are shown. Lines indicate significant age-related changes. Only females show post-adolescent spine pruning, resulting in an adult sex difference in spine density (*day 56 females < males (p<0.02)).
