Table 3.
Top association results in non-Hispanic whites
| RSID | Chr | Position | Beta | SE | P-value | Gene |
|---|---|---|---|---|---|---|
| rs10011796 | 4 | 89090877 | 0.2799 | 0.04959 | 1.99E-08 | ABCG2 |
| rs17211056 | 18 | 73183461 | 0.6488 | 0.1274 | 4.02E-07 | SMIM21 |
| rs3114020 | 4 | 89083666 | 0.2433 | 0.0504 | 1.54E-06 | ABCG2 |
| rs11152031 | 18 | 52533038 | −0.2519 | 0.0522 | 1.54E-06 | CCDC68,RAB27B |
| rs3762427 | 1 | 151867560 | 0.4158 | 0.08677 | 1.82E-06 | THEM4,THEM5 |
| rs2231142 | 4 | 89052323 | 0.323 | 0.06748 | 1.86E-06 | ABCG2 |
| rs2199936 | 4 | 89264355 | 0.3038 | 0.06551 | 3.84E-06 | ABCG2,PKD2 |
| rs12922040 | 16 | 15869466 | 0.2415 | 0.05267 | 4.93E-06 | MYH11,NDE1 |
All SNPs associated with uric acid change in response to allopurinol with P < 5 × 10−6 in a cohort of 1,492 patients of European ancestry. Annotated genes are any gene found within 50 kb of the SNP. Chr, Chromosome. Beta, Beta-coefficient. A positive beta coefficient means that the minor allele is associated with smaller change in SUA from baseline and hence poorer response, whereas a negative beta-coefficient means that the effect allele is associated with larger change in SUA from baseline and hence better response. SE, standard error.