Skip to main content
. Author manuscript; available in PMC: 2015 Jun 24.
Published in final edited form as: J Sex Med. 2011 Oct 13;8(12):3325–3334. doi: 10.1111/j.1743-6109.2011.02500.x

Figure 1. Model of the regulation of antioxidant redox mechanisms.

Figure 1

The Trx and GSH redox systems limit oxidative/nitrosative stress caused by ROS/RNS and function via Trx reductase and GSH reductase enzyme activities. NO may directly cause increased RNS production (via peroxynitrite formation) although NO may also interact with GSH leading to GSNO formation through S-nitrosylation. GSNOR is the major enzyme involved in GSNO metabolism and protects against increased ROS/RNS. (GSSG, glutathione disulfide; S-nitroso-GSH, GSNO; ROS, reactive oxygen species; RNS, reactive nitrogen species; NO, nitric oxide)