A.) In WT mice, maximal ICP significantly decreased after CNI compared with sham treatment while FK treatment increased maximal ICP compared with CNI + vehicle. B.) Total ICP was also significantly decreased after CNI compared with that of sham treatment in WT mice while FK treatment increased total ICP compared with CNI + vehicle. C.) In GSNOR −/− mice, maximal ICP significantly decreased after CNI compared with sham treatment while FK treatment had no effect. D.) Total ICP was also significantly decreased with CNI while FK treatment had no effect. * p<0.05 vs. sham + vehicle, † p<0.05 vs. CNI + vehicle (S +V = sham + vehicle, S + FK = sham + FK treatment, CNI +V = unilateral injury + vehicle, CNI + FK = unilateral injury + FK treatment).