Table 3.
Differentiating PBL from other Neoplasms by Immunophenotyping
| Parameter | PBL | Burkitt | Anaplastic DLBCL | PEL | ALK + DLBCL | PCM/Plasmacytoma | PLASMBLASTIC PCM/Plasmacytoma |
|---|---|---|---|---|---|---|---|
| Clinical presentation | frequently oral cavity | Often extranodal (jaws and orbits) | Wide variety of presentations | Involves body cavity | Wide variety of presentations | BM (Extramedulary in plasmacytoma) | BM (Extramedulary in plasmacytoma) |
| Immunocompetency | +/− | ++ | +++ | +/− | + | ++ | ++ |
| Association with HIV | +++ | ++ | ++ | +++ | - | - | - |
| Association with HHV8 | +/− (usually -) | - | - | + | - | - | - |
| LCA | +/− | + | + | +/− | +/− | +/− | +/− |
| B-Cell Markers | |||||||
| CD20 | - | + | + | +/− | - | - | - |
| CD79a | +/−(usually -) | + | + | - | - | +/− (usually -) | +/− (usually -) |
| CD138 | + | - | - | + | - | + | + |
| CD56 | +/−(usually -) | Rare + | Rare + | Rare + | +/− | Usually + | Usually + |
| Ki67 | High >70 % | High >90 % | High <90 % | High >80 % | High >80 % | Low | High >70 % |
| Other | BLIMP1+ | CD10 + | BCL-6 Usually + | CD30 Usually + | ALK+ | Serum M-spike CRAB | Serum M-spike CRAB |
CRAB: hypercalcemia, kidney disease, anemia, and bone lytic lesions