Table 1.

Clinical data on patients selected for miRNA sequencing and for miRNA identification in plasma

Patient	Site	Gender	Age (yr)	Pathologic stage	Sample	Tissue type	Experiment
p0040	OC-T	Male	48	T4N0M0	microRNA	Tumor	A
p0151	OC-T	Male	47	T3N0M0	microRNA	Tumor	A
p0291	OC-T	Male	55	T4N0M0	Total RNA	Tumor	A
p0340	OC-FOM	Male	51	T4N0M0	microRNA	Tumor	A
p0374	OC-T / OC-FOM	Male	56	T1N2bM0	microRNA	Tumor	A
p0397	OC-FOM	Male	59	T1N3M0	microRNA	Tumor	A
p0418	OC-T	Female	64	T4N0M0	microRNA	Tumor	A
p1022	OC-T	Male	44	T3N0M0	Total RNA	Tumor	A
p1125	OC-T	Male	53	T3N0M0	microRNA	Tumor	A
p1231	OC-FOM	Male	56	T1N2bM0	microRNA	Tumor	A
p1381	OC-FOM	Male	70	T1N2bM0	microRNA	Tumor	A
p1642	OC-T	Male	80	T1N1M0	microRNA	Tumor	A
p0012	OC-FOM	Male	50	T1N1M0	Total RNA	Tumor	A
p0280	OC-FOM	Male	52	T1N2bM0	Total RNA	Tumor	A
p0441	OC-T	Male	54	T1N1M0	microRNA	Tumor	A
p0486	OC-T	Male	56	T3N0M0	microRNA	Tumor	A
p0652	OC-FOM	Male	63	T1N1M0	microRNA	Tumor	A
p0677	OC-FOM	Male	58	T1N2bM0	microRNA	Tumor	A
p1_0250	OP-BT	Male	52	T4aN2aM0	Total RNA	Tumor	B
p1_0301	OP-BT	Male	51	T4N0M0	Total RNA	Tumor	B
p1_0076	OC-T	Male	63	T2N2M0	Total RNA	Tumor	B
p1_0151	OC-T	Male	65	T2N2cM0	Total RNA	Tumor	B
p2_0072	OC-T	Male	53	T3N0M0	Total RNA	Tumor	B
p2_0021	OC-FOM	Male	63	T3N0M0	Total RNA	Tumor	B
p2_0048	OC-FOM	Male	52	T2N2bM0	Total RNA	Tumor	B
p1_0273	OP-BT	Male	68	T1N3M0	Total RNA	Tumor	B
p2_0057	OC-FOM	Male	59	T3N0M0	Total RNA	Tumor	B
p0057	OC-T	Male	57	T4N1M0	microRNA	Tumor	B
p0273	OC-T	Male	56	T4N1M0	microRNA	Tumor	B
p0015	OC-FOM	Male	57	T4N1M0	microRNA	Tumor	B
p0113	OC-FOM	Male	67	T4N0M0	microRNA	Tumor	B
p0166	OC-T	Male	54	T4N0M0	microRNA	Tumor	B
p0335	OC-T	Female	85	T4N0M0	microRNA	Tumor	B
p1_0046	OC-T	Male	54	T4aN2cM0	microRNA	Plasma	C
p1_0105	OC-T	Female	80	T4aN2cM0	microRNA	Plasma	C
p1_0134	OC-T	Male	57	T3N2bM0	microRNA	Plasma	C
p1_0149	OC-T	Male	60	T1N0M0	microRNA	Plasma	C
p1_0151	OC-T	Male	65	T2N2cM0	microRNA	Plasma	C
p1_0328	OC-T	Male	65	T2N0M0	microRNA	Plasma	C
p2_0020	OC-T	Male	58	T2N0M0	microRNA	Plasma	C
p2_0025	OC-T	Male	58	T2N1M0	microRNA	Plasma	C
p2_0068	OC-T	Male	67	T1N0M0	microRNA	Plasma	C
p2_0072	OC-T	Male	53	T3N0M0	microRNA	Plasma	C
p1_0025	OC-FOM	Male	61	T4aN2cM0	microRNA	Plasma	C
p1_0049	OC-FOM	Male	70	T4aN1M0	microRNA	Plasma	C
p1_0061	OC-FOM	Male	50	T4aN2cM0	microRNA	Plasma	C
p1_0111	OC-FOM	Male	55	T1N3M1	microRNA	Plasma	C
p1_0115	OC-FOM	Male	56	T4aN2cM1	microRNA	Plasma	C
p1_0119	OC-FOM	Male	50	T4bN3M0	microRNA	Plasma	C
p1_0220	OC-FOM	Male	50	T1N0M0	microRNA	Plasma	C
p1_0236	OC-FOM	Male	53	T4aN2bM0	microRNA	Plasma	C
p1_0248	OC-FOM	Male	55	T2N2aM0	microRNA	Plasma	C
p1_0308	OC-FOM	Male	50	T4aN0M0	microRNA	Plasma	C
p1_0323	OC-FOM	Male	50	T4aN2cM0	microRNA	Plasma	C
p1_0335	OC-FOM	Female	59	T2N0M0	microRNA	Plasma	C
p2_0021	OC-FOM	Male	63	T3N0M0	microRNA	Plasma	C
p2_0031	OC-FOM	Male	62	T1N2bM0	microRNA	Plasma	C
p2_0035	OC-FOM	Male	57	T1N0M0	microRNA	Plasma	C
p2_0041	OC-FOM	Male	64	T4aN0M0	microRNA	Plasma	C
p2_0048	OC-FOM	Male	52	T2N2bM0	microRNA	Plasma	C
p2_0058	OC-FOM	Male	58	T4N2bM0	microRNA	Plasma	C
p2_0062	OC-FOM	Male	55	T1N0M0	microRNA	Plasma	C
p2_0095	OC-FOM	Male	52	T3N2bM0	microRNA	Plasma	C

OC-T: Oral Cavity – Tongue, OC-FOM: Oral Cavity - Floor of the Mouth. Pathological Stage describes the metastatic status of the samples, with N0 meaning no lymph node metastasis at the time of diagnosis and N > 0 indicating the presence of lymph node metastasis. Experiment description: A- tumor tissue samples used for small RNA sequencing; B – tumor tissue sample used for miRNA expression validation by real-time PCR; C - plasma samples used for miRNA expression detection by real-time PCR