Table 1.
Heart weight and echocardiographic indices
| Control | Hypoxia + Saline | Hypoxia + RC90 | Hypoxia + RC270 | |
|---|---|---|---|---|
| Number of mice | 8 | 8 | 8 | 8 |
| Body weight (BW), g | 21.56 ± 0.56 | 21.95 ± 1.32 | 21.79 ± 1.04 | 20.50 ± 1.44 |
| Whole heart weight (WHW), g | 0.108 ± 0.009 | 0.111 ± 0.007 | 0.109 ± 0.015 | 0.107 ± 0.008 |
| Left ventricular weight (LVW), g | 0.078 ± 0.009 | 0.077 ± 0.008 | 0.076 ± 0.015 | 0.078 ± 0.004 |
| WHW/BW (x104) | 48.28 ± 5.62 | 50.74 ± 4.77 | 50.04 ± 8.22 | 52.73 ± 3.07 |
| LVW/BW (x104) | 37.75 ± 4.43 | 32.65 ± 9.76 | 34.97 ± 8.26 | 38.83 ± 3.26 |
| LVW/WHW | 0.73 ± 0.08 | 0.64 ± 0.19 | 0.69 ± 0.06 | 0.74 ± 0.05 |
| WHW/Tibia, g/mm (x104) | 58.74 ± 4.28 | 56.85 ± 16.99 | 60.79 ± 8.3 | 59.66 ± 4.72 |
| LVW/Tibia, g/mm (x104) | 43.02 ± 4.95 | 39.60 ± 11.79 | 42.40 ± 8.48 | 43.81 ± 2.40 |
| (IVSd), mm | 0.75 ± 0.06 | 0.70 ± 0.04 | 0.72 ± 0.09 | 0.69 ± 0.04 |
| (LVPWd), mm | 0.77 ± 0.08 | 0.61 ± 0.09 | 0.64 ± 0.10 | 0.68 ± 0.09 |
| (LVIDd), mm | 3.74 ± 0.20 | 3.69 ± 0.30 | 3.94 ± 0.16 | 3.58 ± 0.31 |
| (LVIDs), mm | 2.45 ± 0.44 | 2.63 ± 0.33 | 2.62 ± 0.20 | 2.27 ± 0.32 |
| Fractional Shortening (FS), % | 34.80 ± 10.43 | 28.61 ± 7.05* | 33.39 ± 4.29# | 36.64 ± 5.47## |
Values are Mean ± SD. WHW/BW whole heart weight normalized by body weight; LVW/BW left ventricular weight normalized by body weight; LVW/WHW left ventricular weight normalized by whole heart weight; WHW/Tibia whole heart weight normalized by tibia length; LVW/Tibia left ventricular weight normalized by tibia length; IVSd inter-ventricular septum at diastole; LVPWd left ventricular posterior wall thickness at diastole; LVIDd internal dimension at diastole of left ventricle; LVIDs internal dimension at systole of left ventricle; FS: fractional shortening (LVIDd-LVIDs/LVIDd x100)
* P < 0.05, significant differences from the Control group. #P < 0.05, ##P < 0.01, significant differences from the Hypoxia group