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. 2015 Jun 24;12:53. doi: 10.1186/s12977-015-0181-5

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© Valera et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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HDAC6 and A3G co-localize along microtubules in cells. a A series of confocal images, xy sections, shows expression patterns for endogenous HDAC6 and α-tubulin, and overexpressed A3G-3xHA. Different merged images are shown to display endogenous HDAC6/overexpressed A3G-3xHA co-distribution and co-distribution of this complex in the cytoplasm or upon MTs (α-tubulin). In the zoom area (black-bordered inset) is shown the expression of these proteins and their co-distribution, as indicated. b Series of confocal images, xy sections, shows expression pattern for overexpressed EGFP-wt-HDAC6 or A3G-3xHA and α-tubulin. Merged image is shown to display EGFP-wt-HDAC6/A3G-3xHA co-distribution in cytoplasm or upon MTs (α-tubulin). In the zoom area (black-bordered inset) is shown the expression of these proteins and their co-distribution, as indicated. c Series of confocal images, xy sections, shows expression pattern for overexpressed HA-wt-HDAC6, HA-HDAC6-ΔBUZ or A3G-Flag and α-tubulin. Merged image shows HA-wt-HDAC6/A3G-Flag (top) or HA-HDAC6-ΔBUZ/A3G-Flag (bottom) co-distribution in cytoplasm or upon MTs (α-tubulin). From a to c, data are representative of three independent experiments in HEK 293T cells.