Fig. 5.

Locally administered etanercept therapy attenuates mechanical hyperalgesia. von Frey mechanical withdrawal thresholds after SNC or sham operation and locally administered etanercept or vehicle therapy. All animals received two consecutive days of baseline testing before operation. Thereafter, the SNC+vehicle group displayed a mechanical hyperalgesia from 6 to 12 days after the crush. In contrast, the sham-operated, vehicle-treated group (SHAM+vehicle) displayed no mechanical sensitivity to von Frey stimuli. Locally administered etanercept attenuated mechanical hyperalgesia (SNC+etanercept). Data represent the mean withdrawal thresholds (gram force)±SEM of n=8/group. * P<0.05, ** P<0.01 by one-way ANOVA and Dunnett’s post hoc.