Fig. 1.

Effects of anti-ANGPTL3 antibody (REGN1500) on levels and distribution of plasma cholesterol and TG in Ldlr^−/− and Ldlr^−/−;Lrp1^−/− (liver-specific Lrp1 KO) mice. A: Ldlr^−/− and Ldlr^−/−;Lrp1^−/− mice (n = 4–6 males per group, age 10–15 weeks) were injected with control IgG or REGN1500 (10 mg/kg) via the tail vein. Four days later, at the end of the dark cycle, the mice were fasted for 2 h prior to blood sampling. Plasma lipid levels were measured as described in the Materials and Methods. B: Distribution of plasma lipids. Pooled plasma from each group of mice was fractionated by FPLC. Cholesterol and TG levels were measured enzymatically in each fraction. The experiment was repeated and the results were similar. *P < 0.05, **P < 0.01.