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. 2015 Jul;56(7):1308–1317. doi: 10.1194/jlr.M054890

Fig. 1.

Fig. 1.

REGN1500 reduces serum lipid levels in chow-fed C57Bl/6 mice. Serum samples were collected after a 4 h fast from male C57Bl/6 mice (n = 6 per group) 7 days before (Prebleed) and at the indicated days following a single subcutaneous injection of REGN1500 or isotype control antibody (Control Ab) (10 mg/kg). Serum TG (A) and cholesterol (B) were measured enzymatically. C: Plasma levels of mouse ANGPTL3 were measured by ELISA. Serum (20 μl) from each mouse collected 7 days after treatment with REGN1500 or Control Ab (10 mg/kg) were size-fractionated by HPLC. TG (D) and cholesterol (E) were measured in each fraction. Values shown are mean ± SEM, except for the chromatograms where only mean values are shown. Statistical analysis was conducted by two-way ANOVA with Bonferroni correction posttest. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.