Fig. 2.

REGN1500 increases postheparin plasma LPL and improves lipid tolerance. A: Postheparin plasma LPL and HL activity of chow-fed C57Bl/6 mice treated with REGN1500 or control antibody (Control Ab) (10 mg/kg, n = 5 per group). Postheparin plasma was pooled and fractionated on a heparin column to separate HL and LPL, and TG hydrolase activity was measured as described in the Materials and Methods. B: Effect of REGN1500 treatment on plasma TG levels following a lipid tolerance test. Male C57Bl/6 mice were treated with a single dose of REGN1500 or control antibody (10 mg/kg, n = 5 per group) 4 days prior to the intraperitoneal administration of Intralipid (10 μl/g of 20% Intralipid). Values are mean ± SEM. Statistical analysis was conducted by Student’s t-test comparing the groups at each time point. *P < 0.05; **P < 0.01.