Fig. 3.

Weekly administration of REGN1500 reduces serum lipid levels in mice maintained on a high-fat high-cholesterol diet for 8 weeks. Serum samples (Prebleed) were collected from male C57Bl/6 mice (n = 10 per group, 8 weeks old) after a 4 h fast. After 5 days, the mice were placed on a high-fat high-cholesterol diet. Three days later, the mice started receiving a weekly injection of with REGN1500 or isotype control antibody (Control Ab) (25 mg/kg). Serum samples were collected 6 days after each injection following a 4 h fast. Changes in TG (A), TC (B), and LDL-C (C) serum levels are shown. D: Body weights were monitored weekly. E: Liver, epididymal white adipose tissue (epiWAT), and hearts were collected at the end of the study and weighed. F: TG content of liver, epiWAT, and hearts. All values are mean ± SEM. Statistical analysis was conducted by two-way ANOVA with Bonferroni correction posttest. **P < 0.01; ***P < 0.001; ****P < 0.0001