Fig. 4.

REGN1500 reduces HDL-C in WT but not in EL-deficient (Lipg^−/−) mice. Serum samples were collected after a 4 h fast from male chow-fed Lipg^−/− mice and their WT littermates (n = 7 per group) before (Prebleed; 7 days) and 4 days after a single administration of REGN1500 or isotype control antibody (Control Ab) at 10 mg/kg. Serum was analyzed for TG (A) and HDL-C (B). C: Chromatogram showing cholesterol distribution among lipoprotein subclasses after REGN1500 or control antibody administration in WT and Lipg^−/− mice. All values are mean ± SEM, except chromatograms where only mean values are shown. Statistical analysis was by two-way ANOVA with Bonferroni correction posttest. *P < 0.05; **P < 0.01.