Fig. 5.

REGN1500 reduces circulating TG, nonHDL-C, and HDL-C levels in dyslipidemic cynomolgus monkeys. Baseline serum samples were collected at days −15, −7, −2, and 0 following a 16 h fast. Seventeen monkeys were divided into three groups and were administered vehicle or REGN1500 (3 or 10 mg/kg) on day 0 of the study. Serum samples were collected on multiple days and analyzed for TG (A), nonHDL-C (C), LDL-C (D), and HDL-C (E), and are represented as a percent change from baseline. All values are mean ± SEM. Panel (B) shows average changes in absolute TG values before and following treatment with REGN1500 (10 mg/kg). For each parameter, Student’s t-test (two tails, paired) was performed in each group comparing the mean value at each time point to the baseline value. *P < 0.05; **P < 0.01.