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. Author manuscript; available in PMC: 2015 Jun 24.
Published in final edited form as: Neuron. 2014 Dec 17;84(6):1273–1286. doi: 10.1016/j.neuron.2014.11.016

Figure 4. FMRP Loss Induces Fenobam-Reversible Changes in SYNPO Containing Mature Dendritic Spines.

Figure 4

(A) Density ratios of KO/WT synapses containing SYNPO, a marker of mature dendritic spines, reveal no significant change in total SYNPO synapse density (n = 6 pairs).

(B) Analysis of specific synaptic classes reveals significant synapse density changes mediated by FMRP loss in layer 4 VGluT1 synapses and layer 5 VGluT2 synapses.

(C and D) Fenobam treatment normalizes to WT SYNPO-containing synapse density across all classes (n = 6 pairs).

(E) Fenobam application in WT animals induces a density increase in layer 5 synapses (n = 5 pairs).

(F) Fenobam-induced SYNPO synapse density increase is specific to VGluT1 class synapses. Error bars, SE. Significance is calculated using paired t tests, and the p values are adjusted via FDR test. q < 0.05.