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. Author manuscript; available in PMC: 2015 Jun 24.
Published in final edited form as: Neuron. 2014 Dec 17;84(6):1273–1286. doi: 10.1016/j.neuron.2014.11.016

Figure 5. FMRP Loss Specifically Impacts Layer 5 FXR2P-Containing Synapse Density Independent of mGluR5 Signaling.

Figure 5

(A) FXR2P-containing synapse density is significantly depressed in layer 5 cortex of Fmr1 KO in nearly all synapse classes in the study (n = 6 pairs). Layer 4 FXR2P synapses are not perturbed.

(B) This effect is insensitive to fenobam treatment (n = 6 pairs).

(C) Fenobam treatment in WT animals does not affect FXR2P synapses in either layer 4 or 5 (n = 5 pairs). Error bars, SE. Significance is calculated using paired t tests, and the p values are adjusted via FDR test. q < 0.05.