(A) FXR2P-containing synapse density is significantly depressed in layer 5 cortex of Fmr1 KO in nearly all synapse classes in the study (n = 6 pairs). Layer 4 FXR2P synapses are not perturbed.
(B) This effect is insensitive to fenobam treatment (n = 6 pairs).
(C) Fenobam treatment in WT animals does not affect FXR2P synapses in either layer 4 or 5 (n = 5 pairs). Error bars, SE. Significance is calculated using paired t tests, and the p values are adjusted via FDR test. q < 0.05.