(A) GABAergic synapse density in both layers 5 and 4 are elevated in Fmr1 KO animals (n = 6 pairs). Fenobam treatment normalizes to WT layer 4 GABAergic synapse density increase, while it reverses layer 5 GABAergic synapse density increase to a significant decrease (n = 6 pairs).
(B) GABAergic synapses as a percent of total classified synapse is not changed. This suggests that GABAergic synapse density is changing in response to glutamatergic synapse density to maintain a specific ratio.
(A and B) Fenobam treatment in WT does not affect total GABAergic synapse density (n = 5 pairs). Error bars, SE. Significance is calculated using paired t tests, and the p values are adjusted via FDR test. q < 0.05.