Skip to main content
. 2015 Jun 24;10(6):e0130060. doi: 10.1371/journal.pone.0130060

Fig 2. miRNA expression in TRAMP-derived tissues.

Fig 2

A) Global miRNA profiling of prostate cancer (PCa) or prostatic intraepithelial neoplasia (PIN) lesions isolated from TRAMP mice. B) Scatterplot diagram of miRNAs with differential expression of at least 20 folds between PIN and PCa tissues of TRAMP mice. Of the identified 121 deregulated miRNAs (S1 Table) 61 had human orthologs. C, D) Comparison of significant miRNA signatures between prostate cell lines and TRAMP lesions. Only four miRNAs were in common between the two experimental systems. Expression analysis followed by unsupervised hierarchical clustering D) of miR-224, -34b-3p, -138 and miR-34c-5p reveals that androgen-independent prostate cancer cells are more similar to TRAMP tissues than to androgen-dependent or non-tumorigenic prostate human cells.