Table 2.
Effect of D-mannitol, pectin, and praziquantel on body weight, liver weight, and relative liver weight in Schistosoma mansoni-infected mice.
| GROUPS | CONTROL GROUPS | INFECTED GROUPS | TREATED GROUPS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PARAMETER | CONTROL | CONTROL CONS.1 | CONTROL CONS.2 | CONTROL PZQ | 6 WEEKS | 10 WEEKS | 14 WEEKS | CONS.1 4 WEEKS | CONS.1 8 WEEKS | CONS.2 4 WEEKS | CONS.2 8 WEEKS | PZQ |
| Body wt. (g) | 29.04 ± 1.25a | 28.88 ± 0.67a,b | 28.28 ± 0.42b | 27.18 ± 1.08c | 25.53 ± 0.38e | 23.76 ± 0.45f | 21.00 ± 0.49g | 26.34 ± 0.36d | 27.20 ± 0.39c | 25.76 ± 0.31d,e | 26.38 ± 0.32d | 27.64 ± 0.13c |
| Liver wt. (g) | 1.39 ± 0.12g | 1.46 ± 0.15f,g | 1.56 ± 0.2e–g | 1.51 ± 0.22f,g | 2.20 ± 0.15b | 2.39 ± 0.14a | 2.46 ± 0.20a | 1.82 ± 0.13c,d | 1.62 ± 0.1d–f | 1.94 ± 0.14c | 1.75 ±0.1c–e | 1.78 ± 0.1c–e |
| Relative liver wt. | 4.77 ± 0.23h | 5.06 ± 0.55h | 5.57 ± 0.63g,h | 5.54 ± 0.83g,h | 8.63 ± 0.54c | 10.04 ± 1.00b | 11.73 ± 0.99a | 6.93 ± 0.54d,e | 5.97 ± 0.53f,g | 7.51 ± 0.56d | 6.64 ± 0.25e,f | 6.44 ± 0.10e,f |
Notes: Data are expressed as means ± SD of eight mice in each group. p is level of significance, where p < 0.0001 is significant. Analysis of data is carried out by one-way (ANOVA) (analysis of variance) accompanied by post hoc (LSD) (Least significant difference) (CoStat Computer program). Cons.1 means D-mannitol constituent of Ixora undulata Roxb. leaves; Cons.2 means pectin costituent of Linum grandiflorum Desf. leaves, and PZQ means praziquantel, administrated twice.
Unshared letters indicate that these groups are significantly correlated at P < 0.05 while shared letters indicate that these groups are non-significantly. ANOVA p < 0.0001.