Table 3A.
Frequency of treatment compared to Reading Center determined macular fluid location on optical coherence tomography in year 1 of CATT
| Reading Center Determined Fluid Location |
No. of Scans with Fluid Subtype (%) |
No. of PFA: Treatment at Corresponding Study Visit (%) |
No. of PFD: No Treatment at Corresponding Study Visit (%) |
|---|---|---|---|
| IRF only | 1548 (31.7) | 759 (49.0) | 789 (51.0) |
| SRF only | 519 (10.6) | 369 (71.1) | 150 (28.9) |
| Sub-RPE fluid only | 401 (8.20) | 186 (46.4) | 215 (53.6) |
| IRF and SRF | 704 (14.4) | 565 (80.3) | 139 (19.7) |
| IRF and Sub-RPE fluid | 509 (10.4) | 345 (67.8) | 164 (32.2) |
| SRF and Sub-RPE fluid | 434 (8.88) | 380 (87.6) | 54 (12.4) |
| IRF and SRF and Sub-RPE fluid | 773 (15.8) | 686 (88.8) | 87 (11.3) |
| Any IRF | 3534 (72.3) | 2355 (66.6) | 1179 (33.4) |
| Any SRF | 2430 (49.7) | 2000 (82.3) | 430 (17.7) |
| Any Sub-RPE fluid | 2117 (43.3) | 1597 (75.4) | 520 (24.6) |
| Total | 4888 | 3290 (67.3) | 1598 (32.7) |
IRF = intraretinal fluid, SRF = subretinal fluid, RPE = retinal pigment epithelium. RC performed grading of optical coherence tomography scans from as needed dosing patients evaluated during CATT year-one visits (week 4 till week 48). PFA= Positive Fluid Agreement: RC identified macular fluid on OCT and the ophthalmologist administered treatment at the corresponding visit. PFD= Positive Fluid Discrepancy: RC identified macular fluid on OCT and the ophthalmologist did not administer treatment at the corresponding visit when there were no contraindications to treatment. Macular fluid = presence of any one or more of IRF, SRF, or sub-RPE fluid on OCT.