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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Retina. 2015 Jul;35(7):1303–1314. doi: 10.1097/IAE.0000000000000483

Table 6.

Comparison of single largest cross sectional fluid area found on OCT scans from random samples of Positive Fluid Agreements versus Positive Fluid Discrepancies in year 1 of CATT

Positive Fluid Agreement Positive Fluid Discrepancy p-value*
n Median (Q1, Q3) Min Max n Median (Q1, Q3) Min Max
Intraretinal Fluid Area (×10−3 mm2) 74 12.8 (8.67, 21.8) 2.59 129 290 6.28 (3.78, 10.1) 0.60 60.7 < 0.0001
Subretinal Fluid Area (×10−3 mm2) 44 24.9 (10.7, 45.2) 1.26 354 102 5.43 (2.71, 10.9) 1.06 213 < 0.0001
Sub-RPE Fluid Area (×10−3 mm2) 36 45.0 (14.9, 121) 1.87 806 126 10.0 (4.15, 33.6) 0.66 1370 < 0.0004
*

P-value is based on modified version of the Wilcoxon rank sum test to compare median areas of fluid between groups17. Positive Fluid Agreement: RC identified macular fluid on OCT and the ophthalmologist administered treatment at the corresponding visit. Positive Fluid Discrepancy: RC identified macular fluid on OCT and the ophthalmologist did not administer treatment at the corresponding visit when there were no contraindications to treatment. Single largest cross sectional area of intraretinal fluid was approximated as an ellipse using the following formula: area = π × [(Horizontal Dimension/2) × (Vertical Dimension/2)]. Single largest cross sectional area of subretinal fluid and sub-RPE fluid was approximated as a hemi-ellipse using the following formula: area = π/2 × [(Horizontal Dimension/2) × (Vertical Dimension/2)].