Tab. 1.
Single allergens of the house dust and storage mite that have been characterized. All allergens listed are officially listed in the WHO/IUIS allergen database (www.allergen.org)
| Allergen group | Allergen | Protein family | MW (kDa) | Sensitization (%)* |
|---|---|---|---|---|
| 1 | Der p 1 Der f 1 Der m 1 Blo t 1 Eur m 1 |
Cysteine protease | 24 27 25 39 - |
74–00 70–100 - - - |
| 2 | Der p 2 Der f 2 Blo t 2 Eur m 2 Lep d 2 Tyr p 2 Gly d 2 |
Lipid-binding protein | 15 15 - - 16 16 15 |
62–100 >90 - - 88 79 95 |
| 3 | Der p 3 Der f 3 Blo t 3 Eur m 3 Tyr p 3 |
Trypsin | 31 29 - - 26 |
9–97 16 51–100 - 58 |
| 4 | Der p 4 Blo t 4 Eur m 4 |
α-Amylase | 60 56 - |
25–74 4–28 - |
| 5 | Der p 5 Blo t 5 Lep d 5 |
Unknown | 14 14 - |
30–55 20–74 9 |
| 6 | Der p 6 Der f 6 Blo t 6 |
Chymotrypsin | 25 25 25 |
41–65 41 8 |
| 7 | Der p 7 Der f 7 Lep d 7 |
Unknown | 26, 30, 31 30–31 - |
31–53 46 62 |
| 8 | Der p 8 Der f 8 Blo t 8 |
Gluthation-S-Transferase | 27 32 27 |
10–40 - 25 |
| 9 | Der p 9 | Serin protease | 29 | 92 |
| 10 | Der p 10 Der f 10 Blo t 10 Tyr p 10 Lep d 10 |
Tropomyosin | 36 37 33 - - |
6–28 46–81 20–29 - 13 |
| 11 | Der p 11 Der f 11 Blo t 11 |
Paramyosin | 103 98 110 |
42–67 71–87 52 |
| 12 | Blo t 12 | Unknown | 14 | 50 |
| 13 | Der f 13 Blo t 13 Tyr p 13 Lep d 13 Aca s 13 |
Fatty acid-binding protein | - - 15 - 15 |
- 11 - 13 23 |
| 14 | Der p 14 Der f 14 Eur m 14 |
Lipid transfer protein | 177 177 177 |
- 66–84 |
| 15 | Der p 15 Der f 15 |
Chitinase | - 98, 109 |
70 70 |
| 16 | Der f 16 | Gelsolin | 53 | 47 |
| 17 | Der f 17 | Calcium-binding protein | 53 | 35 |
| 18 | Der p 18 Der f 18 |
Chitin-binding protein | - 60 |
63 54 |
| 19 | Blot 19 | Antimicrobial peptide | 7 | 10 |
| 20 | Der p 20 Der f 20 |
Arginine kinase | - 40 |
14–44 50 |
| 21 | Der p 21 Der f 21 Blo t 21 |
Unknown | - 14 13 |
26 - 58–95 |
| 22 | Der f 22 | Unknown | - | |
| 23 | Der p 23 | Peritrophin-like protein | 14 | 74 |
| 24 | Der f 24 Tyr p 24 |
Ubiquinol-cytochrome c reductase-binding protein |
13 18 |
- 11 |
| 25 | Der f 25 | Triosephosphate isomerase | 34 | 60–75 |
| 26 | Der f 26 | Myosin light chain | 18 | 29 |
| 27 | Der f 27 | Serpin | 48 | 35 |
| 28 | Der f 28 | Heat shock protein | 70 | 68–70 |
| 29 | Der f 29 | Cyclophylin | 16 | 70–85 |
| 30 | Der f 30 | Ferritin | 16 | 60–63 |
| 31 | Der f 31 | Cofilin | 15 | 31 |
| 32 | Der f 32 | Inorganic pyrophosphatase | 35 | 15 |
| 33 | Der f 33 | α-Tubulin | 52 | 25 |
MW, molecular weight; Der p, Dermatophagoides pteronyssinus; Der f, Dermatophagoides farinae; Der m, Dermatophagoides microceras; Blo t, Blomia tropicalis; Eur m, Euroglyphus maynei; Lep d, Lepidoglyphus destructor; Tyr p, Tyrophagus putrescentiae; Gly d, Glycyphagus domesticus; Aca s, Acarus siro; —, no information available
*Sensitization rates are based on a number of studies with different patient groups and test systems [enzyme linked immunosorbent assay (ELISA), Immunoblot, ImmunoCAP®, skin test]. Thus they represent merely a guide and not absolute figures.