Table 11.

Risk factors for systemic reactions during AIT (modified from [165, 186, 197, 202])

Current allergy symptoms and potential allergen exposure

Current infections

Mast cell disease

Hyperthyroidism

Unstable or insufficiently treated asthma

A high degree of sensitization

Inadequate dose escalation during initiation

Pharmaceutical use (β-blockers)

Inadequate circulatory stress, excessive alcohol consumption, high-intensity physical exercise, sauna (shortly before and for the rest of the day of injection, augmenting factors should be avoided)

Poor technique of injection

Allergen extract overdose

Manufacturer’s recommendation for dose reduction upon changing to a new production batch was overlooked