TABLE III.
Associations Between Age-Adjusted Telomere Length and Prostate Cancer, Stratified by Timing of Blood Draw Relative to Diagnosis, Johns Hopkins Hereditary Prostate Cancer Family Database
| TL quartilea | No. of affected men | No. of unaffected men | ORb | 95% CI | P-value |
|---|---|---|---|---|---|
| Affected men with blood drawn before or within a year of diagnosis and all unaffected men | |||||
| Q1 | 15 | 16 | 2.26 | (0.40, 12.64) | 0.35 |
| Q2 | 2 | 16 | 0.38 | (0.06, 2.57) | 0.32 |
| Q3 | 7 | 15 | 0.66 | (0.12, 3.67) | 0.63 |
| Q4 | 15 | 16 | 1.00 | — | — |
| P-trend | 0.45 | ||||
| Q1 | 15 | 16 | 3.55 | (0.82, 15.43) | 0.09 |
| Q2–Q4 | 24 | 47 | 1.00 | — | — |
| Affected men with blood drawn after diagnosis and all unaffected men | |||||
| Q1 | 23 | 16 | 0.34 | (0.09, 1.33) | 0.12 |
| Q2 | 14 | 16 | 0.64 | (0.18, 2.28) | 0.49 |
| Q3 | 14 | 15 | 0.70 | (0.20, 2.42) | 0.57 |
| Q4 | 22 | 16 | 1.00 | — | — |
| P-trend | 0.14 | ||||
| Q1 | 23 | 16 | 0.44 | (0.13, 1.45) | 0.17 |
| Q2–Q4 | 50 | 47 | 1.00 | — | — |
a
Quartiles are based on batch-specific cut-points derived from the distribution of age-adjusted telomere length in unaffected men.
b
ORs are adjusted for age and decade of birth and account for clustering by family.