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(I) Membrane SecA complexed with the SecB and preprotein binds to SecYEG; (II) SecA acquires the translocation ATPase activity and inserts itself into SecYEG channel; (III) SecYEG channel loosens and gets ready to push the pre-proteins; and (IV) the preprotein is pushed into the periplasm across the cytoplasmic membrane.
Adapted with permission from [91] © Elsevier (2011).
