. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Future Med Chem. 2015 Jun;7(8):989–1007. doi: 10.4155/fmc.15.42

Table 4.

A comparative account of Rose Bengal and Erythrosine B analogs’ SecA inhibitors and the assays used.

Inhibitor ID	Compound name and structure	Source (year)	Inhibition constants (IC_50s) and assay used				Ref.
Inhibitor ID	Compound name and structure	Source (year)	ATPase	8a	8b	8c	Ref.
8		Synthetic (2012)	In vitro (IC₅₀/μM)				[125,150]
			Unregulated/truncatedN68	0.5	2	ND
			Intrinsic ATPase	25	21	ND
			Membrane bound ATPase	5	12	ND
			Translocation ATPase	0.9	10	2.5
			In vivo (MIC/μM)
			E. coli NR698 (leaky mutant)	3.1	250–500	1.0
			B. subtilis 168	3.1	250–500	6.0
			E. coli (wild type)	>1000	>1000	ND