Figure 4.

AD susceptibility loci CLU displays multiple, independent associations of CpG methylation with neuritic plaque (NP) burden. The figure represents the results of analyses for the CLU region, with the physical position presented on the x axis and −log₁₀ P-values presented in the y axis. Diamonds represent the individual CpGs across the gene region that were tested in the analysis. The state of the chromatin in the dorsolateral prefrontal cortex of a cognitively nonimpaired individual is presented below the x axis; this map is based on the derivation of chromatin state in 200 bp segments using data generated from the immunoprecipitation of chromatin marks. The chromatin states are defined in a box at the top right of the figure.16 The red diamonds are from the primary model testing for NP association. The black diamonds report the results of the primary model with the additional adjustment for the top CpG, cg16292768. All P-values are reported in Table S1.