Table 2.
Assessment of independent associations between CpGs and neuritic plaque burden
| BIN1 | Position | SNP to CG association P-value | CG to NP association | CG to NP association Adjusted for rs744373 | ||
|---|---|---|---|---|---|---|
| CG | β | P-value | β | P-value | ||
| cg22883290 | 127800646 | 1.2E-04 | 4.42 | 3.7E-08 | 4.25 | 5.4E-07 |
| CD2AP | Position | SNP to CG association | CG to NP association | CG to NP association Adjusted for rs9349407 | ||
|---|---|---|---|---|---|---|
| CG | P-value | β | P-value | β | P-value | |
| cg20172563 | 47487173 | 8.1E-25 | 3.48 | 7.5E-06 | 4.10 | 2.8E-06 |
| CLU | Position | SNP to CG association | CG to NP association | CG to NP association Adjusted for rs11136000 | ||
|---|---|---|---|---|---|---|
| CG | P-value | β | P-value | β | P-value | |
| cg16292768 | 27467783 | 1.2E-09 | −2.34 | 3.7E-05 | −2.32 | 1.0E-04 |
| cg08594681 | 27468684 | 1.1E-05 | −2.77 | 0.0008 | −2.68 | 0.002 |
| cg13488078 | 27469338 | 0.0020 | −2.63 | 0.0029 | −2.46 | 0.009 |
| MS4A6A | Position | SNP to CG association | CG to NP association | CG to NP association Adjusted for rs610932 | ||
|---|---|---|---|---|---|---|
| CG | P-value | β | P-value | β | P-value | |
| cg03055440 | 59950405 | 0.0099 | −2.16 | 0.0015 | −2.12 | 0.003 |
All models are adjusted for age at death, sex, study, batch, and bisulfite conversion fraction.