Table 2.
White matter regions showing peak VO2 by age group interaction (listed by descending t-value within each lobe), as well as results of ANCOVA comparing YA, HFOA, and LFOA
| White matter region | Hem | Volume (mm3) | % ROI | Mean t-value | SD | ANCOVA F-value | ANCOVA follow-up |
|---|---|---|---|---|---|---|---|
| Frontal | |||||||
| Pars orbitalis | L | 30 | 47.6 | 1.84 | 0.57 | 2.77 | YA > LFOA |
| Superior frontal | R | 922 | 30.7 | 1.81 | 0.60 | 12.17 | YA > HFOA > LFOA |
| Body of cc | M | 1964 | 62.6 | 1.86 | 0.63 | 10.82 | YA > HFOA > LFOA |
| Ant limb of ic | L | 90 | 11.0 | 1.81 | 0.53 | 6.28 | YA and HFOA > LFOA |
| External capsule | L | 642 | 44.9 | 1.80 | 0.64 | 3.67 | YA and HFOA > LFOA |
| Pars opercularis | L | 325 | 35.5 | 1.76 | 0.61 | 11.65 | YA > HFOA > LFOA |
| Genu of cc | M | 776 | 44.1 | 1.68 | 0.53 | 9.44 | YA > HFOA > LFOA |
| Parietal | |||||||
| Pos corona radiata | L, R | 409, 524 | 54.5, 63.4 | 1.74, 1.88 | 0.60, 0.68 | 5.52, 6.73 | YA and HFOA > LFOA, YA and HFOA > LFOA |
| Postcentral | R | 445 | 34.2 | 1.79 | 0.70 | 2.47 | YA and HFOA > LFOA |
| Pos thalamic radiation | R | 540 | 47.2 | 1.75 | 0.64 | 6.73 | YA > HFOA and LFOA |
| Paracentral | R | 312 | 40.4 | 1.72 | 0.49 | 4.83 | YA and HFOA > LFOA |
| Superior parietal | L | 857 | 26.3 | 1.71 | 0.61 | 6.88 | YA and HFOA > LFOA |
| Precuneus | L | 293 | 22.8 | 1.70 | 0.51 | 9.01 | YA > HFOA > LFOA |
| Temporal | |||||||
| Temporal pole | R | 39 | 32.2 | 2.48 | 0.96 | 1.52 (ns) | |
| Fornix (stria) | L, R | 104, 150 | 25.9, 47.9 | 1.81, 1.94 | 0.64, 0.63 | 4.14, 4.70 | YA > LFOA, YA > HFOA and LFOA |
| Sagittal stratum | L, R | 311, 382 | 64.9, 64.1 | 1.94, 1.76 | 0.81, 0.59 | 3.66, 3.65 | YA and HFOA > LFOA, YA and HFOA > LFOA |
| Superior temporal | L | 1111 | 40.8 | 1.81 | 0.67 | 4.17 | YA and HFOA > LFOA |
| Banks sts | L | 185 | 33.6 | 1.77 | 0.51 | 9.95 | YA and HFOA > LFOA |
| Occipital | |||||||
| Cuneus | L, R | 152, 122 | 37.7, 53.3 | 1.75, 1.71 | 0.55, 0.56 | 2.49, 2.18 (ns) | YA > LFOA |
| Pericalcarine | R | 409 | 49.7 | 1.74 | 0.60 | 6.14 | YA and HFOA > LFOA |
| Fusiform | L, R | 317, 684 | 19.4, 43.7 | 1.70, 1.71 | 0.60, 0.50 | 3.49, 3.10 | YA and HFOA > LFOA, YA and HFOA > LFOA |
| Splenium of cc | M | 784 | 34.1 | 1.71 | 0.53 | 3.83 | YA and HFOA > LFOA |
| Lateral occipital | L | 312 | 22.9 | 1.69 | 0.59 | 7.00 | YA > HFOA > LFOA |
Percent of ROI represents the percentage of the TBSS skeleton ROI showing the peak VO2 by age group interaction. Mean and SD are based on t-values of each voxel within the ROI. Two values within a single cell represent the left and right region, respectively. ANCOVA, analysis of covariance; YA, young adults; HFOA, higher fit older adults; LFOA, lower fit older adults; ROI, region of interest; L, left; R, right; cc, corpus callosum; M, mid-line; ant, anterior; ic, internal capsule; pos, posterior; sts, superior temporal sulcus; TBSS, Tract-Based Spatial Statistics.