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. 2015 Apr 17;2(6):699–706. doi: 10.1002/acn3.200

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© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Quantitation of caspase 3 and phospho-mTOR (pSer2448) levels in VGB-treated mice. Animals received VGB (35 mg/kg) using three successive i.p. administrations over a 24 h period. Caspase 3 activity is a direct measure of the mammalian apoptosis pathway, while phospho-mTOR level indicates the increased activation of the PI-3 kinase pathway and activational status of mTOR. *P < 0.05, unpaired one-tailed t test, which was employed since we predicted enhanced apoptosis and phospho-mTOR production. See Figure2 legend for x-axis details. mTOR, mechanistic target of rapamycin; VGB, vigabatrin.