Table 3.

Phenotypes of T-cell-mediated experimental animal models in miR-155-deficient mice

Model	Effector cells	Phenotype	Cytokines	References
CD4-dependent
Tumour transplantation	Th1	Enhanced tumour growth	IFN-γ↓	32
Salmonella typhimurium	Th1	Reduced optimal response	IFN-γ↓	11
Delayed-type hypersensitivity	Th1, Th17	Less severe	IL-17↓, IFN-γ↓, IL-6↓	26
Helicobacter pyroli	Th1, Th17	Bacteria not eliminated	IFN-γ↓, IL-17↓	27
Asthma/HDM	Th2	Less severe	IL-13↓	35
Asthma/OVA	Th2	Less severe	IL-4/5/13↓	33
Heligmosomoides polygyrus	Th2	Helminth not eliminated	IL-13↓	35
Collagen-induced arthritis	Th17, Th1	Less severe	IL-17↓, IFN-γ↓	12,13
EAE	Th17, Th1	Less severe	IL-17↓, IFN-γ↓	25,26
Toxoplasma gondii	Th17, Th1	Reduced optimal response	IL-17↓	36
CD8-dependent
Influenza	CD8	Virus not eliminated	IFN-γ↓	46
Listeria monocytogenes	CD8	Reduced optimal response	IFN-γ↓	46,47
Lymphocytic choriomeningitis	CD8	Reduced optimal response	IFN-γ↓	47
Murid herpesvirus 68	CD8	Virus not eliminated	IFN-γ↓	45
Tumour transplantation	CD8	Enhanced tumour growth	IFN-γ↓	32

EAE, experimental autoimmune encephalomyelitis; HDM, house dust mite; IFN-γ, interferon-γ; IL-6, interleukin-6; OVA, ovalbumin; Th, T helper.