Figure 4.

In healthy individuals high expression of CD26 or CD161 defines the same subset of CD8⁺ TRAV1–2⁺ cells that predominantly express the CD8αβ co-receptor. Expression of CD26 and CD161 on CD8α⁺ TRAV1–2⁺ cells from peripheral blood mononuclear cells of healthy individuals is shown (top row). The numbers represent the frequencies of CD8α⁺ TRAV1–2⁺ cells that co-express CD26^hi and CD161^hi (46 ± 13; n = 4). The bottom row represents CD8β expression (y-axis) from the CD8α⁺ TRAV1–2⁺ CD26^hi CD161^hi gated cells from the top row. The numbers in the plot represent the frequency of CD8α⁺ TRAV1–2⁺ CD26^hi CD161^hi that co-express CD8β (72·6 ± 6·7; n = 4).