Substance group according to site of action	Chemical name	Non-allergic intolerance	Immediate-type reaction	Uncomplicated rash	Hypersensitivity syndrome	Bullous skin reaction	Cytopenia	Other
Cyclooxygenase inhibitors	ASA and NSAID	frequent	–	rare	–	rare	–	rare
P2Y12 inhibitors	Thienopyridine/ticagrelor	–	rare	occasional	rare	isolated	–	rare
Glycoprotein IIb/IIIa receptor antagonists	Fibans/abciximab	–	rare	isolated	–	–	frequent	–
Phosphodiesterase inhibitors/dipyridamole	Quinolinone derivative/dipyridamole	–/–	-/rare	–/isolated	isolated/–	isolated/isolated	–/–	–/–
Vitamin K antagonists	Coumarins	–	isolated	rare	–	isolated	–	isolated
Antithrombin-III activators (heparins)	Glycosaminoglycans	–	isolated	frequent	–	rare	–	occasional
Direct factor Xa inhibitors	Xabans, oxazolidinones	–	iolated	rare	–	–	–	isolated
Direct thrombin inhibitors	bivalent polypeptide hirudin derivatives, nonpeptide thrombin inhibitors	–	–	rare	–	isolated	–	–

No data given (–): insufficient information available